Seville's compact airport and Andalusia's slow, sherry-soaked rhythm make an odd bookend to BWI's efficient, no-frills terminal, and that contrast is exactly why this route rewards careful routing. There is no nonstop option: business class from Baltimore to Seville always involves a connection, typically through London Heathrow via British Airways or through Philadelphia/Charlotte and Madrid via American Airlines and Iberia, given the joint transatlantic venture these three carriers operate. My preference, after flying this corridor repeatedly, is the BA routing on the transatlantic long-haul in their Club Suite — the door-equipped, direct-aisle-access seat now standard on Heathrow's 777s and A350s — followed by a short Iberia or BA hop down to Seville, which uses narrowbody business class seating (a blocked middle seat rather than a lie-flat product, so treat it as a shuttle, not a splurge leg).
If you route through Madrid instead, Iberia's A330 and A350 business class offers a solid lie-flat product with decent Priority Pass lounge access at Barajas, and connection times there tend to run tighter and more reliable than Heathrow's, which can eat two hours if you're unlucky with immigration queues. An insider trick worth knowing: booking the BWI–Philadelphia segment on American rather than starting at BWI's limited international check-in desks often smooths through-baggage handling for the whole itinerary, since American's PHL hub has dedicated priority lanes for AAdvantage elites and oneworld Sapphire/Emerald status holders that BWI simply doesn't offer for this routing.
April, May, September, and October are consistently the sweet spot — Seville's brutal summer heat keeps demand and seat availability more favorable in shoulder season, while ferias and flamenco festivals in spring can tighten award space fast. Because pricing and premium cabin inventory on this three-airline partnership shift constantly with Atlantic joint-venture scheduling, setting up fare alerts specifically for the Baltimore–Seville corridor is the smartest way to catch a business class fare before it disappears.