Nuremberg's modest regional airport has never hosted a widebody flight from the American South, which is precisely why anyone routing business class from Birmingham to Nuremberg needs to think in two legs rather than one. There is no nonstop option, so the real decision is which American carrier gets you across the Atlantic in the right seat, then hands you off cleanly for the short intra-European hop into Franconia. Delta, American, and United all serve this corridor via their respective hub-and-partner networks, and the correct answer is that Birmingham to Nuremberg business class travelers should prioritize the transatlantic segment's seat product, since the final European connector is almost always a standard short-haul business cabin regardless of carrier.
My preference after years on this exact itinerary is Delta out of Atlanta, where the A350's fully suited, all-aisle-access business class makes the long domestic-to-international connection painless, followed by a Lufthansa or partner flight into Munich or Frankfurt before the final push to Nuremberg. American routes efficiently through Philadelphia or Charlotte with its Flagship Suite on select widebodies, while United's Polaris seats out of Newark or Chicago offer another strong option, particularly if your Birmingham departure timing favors an evening transatlantic push that lands you in Germany with a full day ahead. The insider move here: book the Nuremberg connection with enough buffer—at least two hours—since German regional carriers routing through Frankfurt or Munich can be affected by the notoriously tight morning slot congestion at both hubs, and a missed connection into NUE often means a multi-hour wait for the next puddle-jumper.
Seasonally, January through March and again in October and November reward patient travelers, as Germany's trade-fair calendar (particularly Nuremberg's toy and consumer goods expos) quiets down outside peak months, softening premium cabin availability. Given the routing complexity and multiple carrier options, setting fare alerts across all three airlines is the smartest way to catch the inevitable pricing dips before they disappear.