There's a peculiar satisfaction in routing through a hub city on your way to Porto's riverside charm, and after many crossings on this exact itinerary, I can say plainly: there is no nonstop business class from Birmingham to Porto, so the real decision isn't whether to connect, but where. Birmingham-Shuttlesworth's transatlantic options funnel primarily through Delta, American, and United gateways, and each carrier's flagship business product transforms what would otherwise be a routine connection into the best part of the trip. Delta's Delta One suites (with sliding privacy doors on many widebody aircraft) out of Atlanta or JFK offer some of the most consistent hard-product reliability in the U.S. fleet, while United's Polaris seats, routed through Newark or Washington Dulles, pair well with United's genuinely strong Star Alliance connectivity into Porto via Lisbon or Madrid. American, for its part, leans on Flagship Suites out of Philadelphia or Charlotte, with onward legs typically routed through London or Madrid before the short hop to OPO.
My strong preference, built from repeated trial and error, is routing through Lisbon rather than Madrid when connecting onward to Porto — Lisbon's shorter walking distances and more predictable immigration lines make for a far less stressful arrival, especially after an overnight transatlantic leg. If you have flexibility, build in a two-hour buffer at whichever European hub you choose; Iberian ATC delays are common in peak summer months, though far less so in the shoulder seasons. That's precisely why January, February, March, October, and November are the sweet spot for this routing — not just for lower business class fares, but because connection reliability improves noticeably once the July-August crowds thin out.
Given how much these fares fluctuate by connection point and season, this is a route where setting up automated fare alerts pays real dividends — tracking Birmingham to Porto business class pricing across Delta, American, and United simultaneously will reveal patterns that manual searching simply won't catch.