There's no nonstop route between Idaho's high desert and Tuscany's hills, which is precisely why the routing decision matters more than the fare itself. Business class from Boise to Florence always requires at least two connections, since BOI's regional runway can't accommodate the widebodies that make the transatlantic haul, and Florence's compact Peretola airport handles mostly short-haul European traffic. The practical answer for most travelers: connect through a major US or European hub, then transfer to Rome or Pisa before a short hop or scenic train into Florence proper. Lufthansa routes efficiently through Frankfurt or Munich, where their newer Allegris business class suites (still rolling out fleet-wide, so worth confirming aircraft type at booking) offer sliding privacy doors and genuinely restful bedding. Air France funnels through Paris CDG, pairing well with their business class on the Boeing 777 or A350, featuring flat-bed seats and a strong Clos d'Ellis wine list that makes the second leg feel less like an afterthought. ITA Airways, the most Italy-centric option, connects through Rome Fiumicino with their A330 business cabin, then a quick onward flight to Florence or a two-hour train ride that many seasoned flyers actually prefer for the scenery alone.
My insider tip after flying this corridor repeatedly: skip the tight FLR connection entirely and fly into Pisa instead, then take the direct train to Florence's Santa Maria Novella station—it's often faster door-to-door than waiting for a puddle-jumper, and it avoids the operational fragility of small regional airports during Tuscan thunderstorm season in late summer.
Timing your booking matters as much as choosing your carrier. April, May, September, and October consistently offer the best combination of fare value and pleasant Tuscan weather, avoiding both the August crowds and the shoulder-season price spikes that hit around Easter and the fall harvest season. Given how much fares fluctuate on this three-carrier, multi-connection route, setting up automated fare alerts is the smartest move—letting the data do the watching while you focus on planning the Florence itinerary itself.