Ibiza's runway can't handle widebody jets, which is the single fact that shapes every itinerary on this route: there's no nonstop option, and business class from Boston to Ibiza always routes through a European gateway before a short connecting hop on a narrowbody. The most reliable path runs through Madrid on Iberia, whose A330 and A350 business class delivers fully lie-flat seats and a genuinely Spanish culinary program worth savoring before that final 45-minute jump on an A320 in a domestic-style business cabin. London via British Airways works too, especially if you can snag Club Suite on the transatlantic leg out of Heathrow Terminal 5, though the BOS-LHR sector on older 777s sometimes still runs the previous Club World seat — worth checking your specific aircraft before booking. Lufthansa routes through Frankfurt or Munich, and while their long-haul product (including the newer Allegris cabins on select aircraft) is excellent, this adds a second connection most travelers find less efficient than the Iberia routing.
My strong preference after years flying this corridor is Madrid: Iberia's T4 satellite terminal has one of the smoother connection experiences in Europe, and the airline's Business Plus lounge access lets you reset properly before the final hop. One insider tip that rarely gets mentioned — book the connecting Ibiza flight as a single ticketed itinerary rather than separately, because Iberia will protect you on delays and rebook you automatically if Ibiza's notoriously wind-affected runway causes diversions, which happens more than travelers expect in shoulder season.
Shoulder months — April, May, September, and October — bring both better weather for that Ibiza approach and noticeably more availability in Iberia's premium cabins, since summer capacity gets absorbed by leisure demand months in advance. Given how much fares fluctuate on this itinerary depending on Iberia's Madrid connection loads, setting up fare alerts well ahead of your travel window is the smartest way to catch a business class fare before it disappears.