There's no nonstop route between Boston and Valencia, which means every business class from Boston to Valencia itinerary routes through either Madrid, London, or another European gateway — and that connection choice matters more than most travelers realize. Iberia's daily BOS-Madrid service, operated on Airbus widebodies with their Business Class flat-bed seats, feeds neatly into a short Iberia hop down to Valencia, making Madrid the most logical single-connection option since both segments sit on the same ticket and often the same alliance. British Airways offers an alternative via London Heathrow, where you can experience the Club Suite with its direct-aisle access and closing door on the transatlantic leg before transferring to a short BA or codeshare connection into Valencia; American Airlines, as Iberia and BA's joint-business-agreement partner, frequently prices into these same routings, so it's worth checking AA's own metal out of Boston if their transatlantic widebody schedule aligns with your dates.
I've flown the Madrid connection more often than the London one simply because Iberia's Barajas terminal makes transferring from long-haul arrivals to the Valencia shuttle far less stressful than navigating Heathrow's T5 during peak banks — arrive at T5 with at least two hours if you're connecting onto a BA European flight, since immigration and security recheck can eat your buffer fast. My insider tip: book the Iberia Madrid-Valencia connector as a separate short-haul business fare only if your main transatlantic ticket doesn't already include it — Iberia's domestic Spanish business product is modest, so on tight connections it's sometimes smarter to accept a slightly longer layover in Madrid and enjoy the Iberia lounge rather than sprint for a marginal seat upgrade.
Shoulder season — April, May, September, and October — consistently delivers the best combination of fare value and pleasant Valencia weather, avoiding both the summer crush of Spanish tourism and Boston's icier winter transatlantic schedules. Because fares on this three-airline corridor fluctuate with Iberia and BA's competing promotional cycles, setting up automated fare alerts is the smartest way to catch a business class fare dip before it disappears.