There's no nonstop path for business class from Charleston to Alicante, which means the routing itself becomes part of the strategy, and after years of piecing this journey together, I've found that the connection city matters as much as the cabin you book. American Airlines, British Airways, and Iberia all share metal on this corridor through their joint transatlantic venture, and the most reliable itinerary funnels through either Charlotte or Philadelphia to a London or Madrid gateway before the final hop to Alicante's compact, easy-to-navigate terminal. The factual baseline worth knowing: total flight time across the Atlantic segment runs roughly 9.5 hours, and connecting via Madrid on Iberia often shaves overall travel time compared to routing through London.
I favor the Iberia option through Madrid when schedules allow, since their A330 business class delivers a comfortable lie-flat product and Barajas is far more forgiving for a tight connection than Heathrow, where Terminal 5's security and immigration lines can eat your buffer fast. If British Airways is your carrier of choice instead, their Club Suite—with its sliding door and direct aisle access—is now rolling out across more widebody aircraft, though you'll want to confirm the specific tail number on your Charlotte-to-London leg, as older Club World cabins without doors still fly certain routes. My insider tip: book the Charleston-to-hub domestic segment as late in the day as scheduling permits, since this gives you a buffer against the notorious Southeastern thunderstorm delays that plague CHS departures from June through August, protecting your international connection.
April, May, September, and October remain the sweet spot for this itinerary, not just for shoulder-season fares but because Alicante's Costa Blanca weather is genuinely more pleasant than the peak summer crush. Given how much these fares swing week to week depending on which carrier is discounting its transatlantic inventory, setting up automated fare alerts for this specific routing is the smartest move you can make before booking.