There is no nonstop path between the Lowcountry and the Algarve, which is precisely why booking business class from Charleston to Faro rewards a bit of routing savvy. With no direct service, the smartest itineraries funnel through Atlanta on Delta, connecting to a transatlantic partner, or route via London or Lisbon on British Airways and TAP Air Portugal respectively. My preferred build is Delta's domestic hop from CHS into Atlanta's Concourse E for an easy international transfer, then onward on a Delta One product (Suites on the A330-900 or 767 depending on gateway) across to a European hub, followed by a short regional connection into Faro—TAP's own Lisbon-Faro shuttle is quick and frequent, and TAP's A321neo business class, while not lie-flat, is perfectly comfortable for the 50-minute final leg.
The London routing via British Airways deserves consideration too: Club Suite, with its sliding door and direct aisle access, now flies on select 777 and A350 aircraft out of Heathrow, and connecting through T5 is efficient if you've allowed at least two hours—security requeuing for US arrivals can eat time during peak summer months. My insider tip: avoid July and August connections through Heathrow entirely if possible, as T5's security lines swell with holiday traffic; instead, funnel through Lisbon on TAP, where immigration for EU arrivals is fast and the Faro leg feels like a domestic puddle-jumper.
Faro itself is a seasonal airport—winter schedules thin out considerably, so shoulder-season travel isn't just about fare savings, it's about flight availability. April, May, September, and October consistently deliver the best value and the most reliable connection banks, since airlines add frequencies for the Algarve's golf and beach crowds without the August crush. Given the multiple routing options and partner airline dynamics at play here, this is a route where fares fluctuate more than most transatlantic itineraries—setting up automated fare alerts will save you from manually checking three carriers across two connection cities every week.