There is no nonstop path linking these two airports, which means every itinerary in business class from Charleston to Tirana routes through at least one major European or Turkish hub, and the routing you choose matters as much as the fare itself. My preferred build is Charleston to Atlanta on Delta, then a long-haul hop on Delta One to Amsterdam or Paris, followed by a partner or Delta-marketed connection into Tirana; the alternative, and often the more comfortable one, is connecting through Istanbul on Turkish Airlines, whose widebody business cabin and Istanbul Airport lounge remain among the most underrated luxury experiences in international travel. Lufthansa via Frankfurt or Munich is the third real option, and depending on aircraft assignment you may find yourself in the newer Allegris business suite rather than the older long-haul product, which is worth checking at booking since Lufthansa has been rolling out Allegris unevenly across its fleet.
Having flown all three routings multiple times, my strongest recommendation is Istanbul: Turkish Airlines' business class includes a proper multi-course service and their Istanbul lounge has a level of culinary theater — live cooking stations, a chocolate room — that turns a long layover into part of the trip rather than a burden. If you're routing through Frankfurt or Munich instead, build in extra connection time in winter months, since fog delays are common and Lufthansa's short intra-European hops to Tirana operate with tighter schedules than the transatlantic legs. One insider tip: Tirana's airport is small and immigration can bottleneck quickly after a wide-body arrival, so if your itinerary lands with other business class passengers from a Gulf or European hub simultaneously, request early deplaning from the crew — it saves real time.
Fare-wise, January through March and again in October and November consistently produce the softest pricing on this corridor, as Balkan leisure demand drops and carriers discount premium cabins to fill them. Given how much these fares fluctuate week to week across three very different routings, setting up fare alerts is the smartest way to catch a genuine deal before it disappears.