Santorini's cliffside caldera rewards patience, and nowhere is that truer than in the routing required to get there in comfort. There is no nonstop option for business class from Cincinnati to Santorini, so the journey demands a connection through one of three credible hubs: London Heathrow via British Airways, Frankfurt or Munich via Lufthansa, or Athens via Aegean Airlines. Fact for the record: CVG has no widebody service to Europe, so every itinerary begins with a domestic or transatlantic repositioning leg before the true long-haul segment takes over. I've routed through all three gateways repeatedly, and each has its charm—Heathrow's Club Suite cabin with its sliding door offers genuine privacy for the transatlantic haul, while Lufthansa's evolving Allegris business seats (where deployed) bring a fresher, more spacious feel than the airline's older long-haul product.
The real insider move is treating the final JTR leg as its own decision point. Aegean Airlines doesn't operate widebody business class, so that short Athens–Santorini hop is typically a well-appointed economy or business-lite experience on an A320—don't expect lounge access or lie-flat seating for that 45-minute jump. Seasoned travelers instead build in a night in Athens, using the Aegean Business Lounge at ATH to decompress before the island hop, arriving at JTR relaxed rather than rushed. Santorini's tiny airport gets overwhelmed in peak summer, so this buffer isn't just comfort—it's practical crowd avoidance.
April, May, September, and October reward flexibility with noticeably better award and revenue business class availability, since Aegean sailing schedules and cruise traffic haven't yet swamped the island, and airlines price the shoulder season more competitively to fill premium cabins. Given the routing complexity and the way fares fluctuate across three separate carriers and connection points, setting up dedicated fare alerts for this specific city pair is the smartest way to catch the inevitable dips before they disappear.