Split's Adriatic charm rewards patience, and after a decade of routing through European hubs to reach this Dalmatian gem, I can tell you there's no shortcut: business class from Cincinnati to Split requires a connection, since no US carrier flies CVG nonstop to Croatia. Delta, American, and United all serve the route via their transatlantic gateways—Delta through Amsterdam or Paris on its A330/A350 fleet with the Delta One suite, American via London Heathrow or Frankfurt using their 777/787 Flagship Business or Business seats, and United through Frankfurt or Munich aboard 767s and 777s in Polaris. Total travel time runs close to 10 hours of actual flying once you factor in the connection, and Delta's Amsterdam routing tends to offer the smoothest onward hop into Split, especially during the June-through-September charter season when Croatia Airlines and seasonal EU carriers pack SPU's modest terminal.
My strong preference is Delta's Amsterdam connection, where the Schiphol layover allows access to the KLM Crown Lounge for a proper shower and rest before the short intra-European hop—something you won't get connecting through Frankfurt or Heathrow, both notorious for security bottlenecks during peak summer travel. If you're using American, route through London and build in at least two hours, as Heathrow's Terminal 3 to Terminal 5 transfers (depending on which lounge you use) can eat your buffer fast. United's Munich connection is underrated for this itinerary—Lufthansa's ground handling there is efficient, and the Polaris lounge access at IAD before departure sets the tone for the long day ahead.
The sweet spot for this itinerary falls in April, May, September, and October, when Split's tourist crush eases but weather remains ideal for wandering Diocletian's Palace or hopping to Hvar. Award availability on Delta One tightens dramatically for July departures, so shoulder-season flexibility is your best leverage. Given how erratically fares fluctuate on this three-airline, one-stop route, setting up automated fare alerts is the smartest move you can make before booking.