Montpellier's compact airport, with its single runway serving little more than regional and seasonal European traffic, will never host a widebody from Ohio directly—so the real strategy for business class from Columbus to Montpellier lies in choosing the right European gateway. There is no nonstop option here, full stop; the smartest routing pairs Delta or Air France through Paris CDG, or Lufthansa through Frankfurt or Munich, with a short connecting hop into MPL on a regional jet. Delta's transatlantic metal, often in partnership with Air France, gets you into CDG where Air France's own A350 business class—with its suite-style seat and sliding door—offers one of the more private hard products currently flying the Atlantic. Lufthansa routes funnel through Frankfurt or Munich, and depending on aircraft assignment, you may catch the airline's newer Allegris cabin, though on this city-pair it's more common to see the long-serving 747-8 or A350 business seat, still comfortable and reliably staffed by Lufthansa's meticulous cabin crews.
Having flown this corridor more times than I can count, my strongest advice is to build in at least a two-hour connection at CDG if you're transferring onto the Montpellier regional leg—Terminal 2E's satellite gates require significant walking and sometimes a shuttle bus, and missed connections here aren't uncommon during peak summer congestion. An insider tip few travelers know: booking the CDG-MPL segment as part of the same Air France ticket (rather than separately) automatically protects you with rebooking rights if the short-haul flight is delayed, which happens more often than the airline advertises given Montpellier's limited slot availability.
Winter and shoulder-season months—January, February, March, October, and November—consistently deliver the softest business class fares on this route, as leisure demand for the south of France dries up outside summer. Because pricing fluctuates weekly depending on which hub and carrier combination opens award or discounted space, setting up fare alerts is genuinely the smartest move before booking this itinerary.