Rhodes rewards patience, and after a dozen trips threading Aegean sunsets through connecting itineraries, I can tell you there's no nonstop shortcut here—every business class from Detroit to Rhodes routing runs through a major European hub, with total journey time (including connection) typically stretching past the 11.5-hour flying segment alone. The most reliable path is Lufthansa via Frankfurt or Munich, where Allegris-equipped aircraft on the transatlantic leg now offer proper suites with sliding doors on select routes—worth checking your specific aircraft assignment before booking. British Airways via London Heathrow offers Club Suite with direct aisle access from every seat, a meaningful upgrade over BA's older Club World cabins, though you'll want Terminal 5 for the smoothest transfer given its dedicated BA infrastructure. Aegean Airlines, Greece's flag carrier, typically handles the final short-haul hop from Athens or another Greek gateway into Rhodes, and while their intra-European business class is more regional recliner than lie-flat suite, it's a comfortable, short finish to a long journey.
My insider tip: build in a 3-4 hour connection window in Frankfurt or Munich rather than the minimum legal connection time—Lufthansa's business class lounges there are genuinely worth savoring, and tight connections through German hubs during peak summer months (June-August) run higher misconnection risk than most travelers expect. Instead, target April, May, September, or October, when Rhodes' tourist crush thins out, Mediterranean weather remains gorgeous, and premium cabin availability opens up considerably across all three carriers.
Arrival in Rhodes itself is refreshingly low-stress—the airport is compact, and business class passengers connecting through Athens often clear customs and immigration formalities before the final short hop, simplifying the last leg. Given how fare classes shift week to week on this multi-carrier routing, setting up automated price tracking for Detroit-Rhodes business class fares is the smartest move you can make before committing to dates.