Detroit's Delta hub makes the Motor City an unexpectedly civilized launch point for Central Europe, and after logging this crossing more times than I can count, I can say definitively: there is no nonstop business class from Detroit to Vienna. Delta does not operate the route directly, so the practical answer is routing through a European gateway, typically Amsterdam or Paris via Delta's own metal, or connecting onto Austrian Airlines through Frankfurt or Munich via Star Alliance partner United. Delta's A330-900neo and A350 both feature the reverse-herringbone Delta One suite with a closing door, a product that has genuinely elevated the transatlantic experience, and if your itinerary routes through Amsterdam, the connection to Vienna is typically short and manageable even with modest layover buffers.
For those willing to build a longer connection, flying United out of Detroit's own terminal to a hub like Newark or Washington Dulles, then transferring to Austrian Airlines' Boeing 777 or A321 for the final leg into Vienna, delivers a distinctly different flavor: Austrian's business class isn't flashy, but the Do&Co catering is a genuine highlight, and their Vienna arrivals process is refreshingly efficient if you've checked bags through. My insider tip, learned the hard way after a tight Munich connection years ago: when routing through German hubs in winter, always add at least 90 minutes of buffer, since de-icing delays are common between November and February and can cascade quickly through Lufthansa Group's schedule, which Austrian belongs to.
Seasonality matters enormously on this corridor. January, February, March, October, and November consistently offer the softest business class fares, as Vienna's peak tourist crush (Christmas markets aside) and summer festival season drive premiums the rest of the year. Because there's no single dominant nonstop carrier keeping fares in check, pricing on this Detroit–Vienna corridor can swing unpredictably week to week — which is exactly why serious travelers on this route keep automated fare alerts running rather than checking manually.