Dubrovnik's medieval walls and Adriatic light reward the effort it takes to get there, and that effort is considerable given there's no nonstop option for business class from Fort Lauderdale to Dubrovnik. The reality is that every itinerary routes through a major hub, with American, Delta, and United each offering credible paths via their transatlantic gateways—American through Philadelphia or Charlotte connecting to a European partner, Delta via JFK or Atlanta into its own long-haul metal, and United through Newark. Total journey time typically stretches to 14-16 hours once you factor connections, though the transatlantic leg itself runs close to 11 hours. Delta's A330 and A350 business class, with lie-flat seats and Delta One suites on select aircraft, tends to offer the most consistent product for the transatlantic segment, while United's Polaris seating on its 767 and 777 fleet is a reliable alternative if your connection routes through Newark or Washington Dulles.
Having flown this corridor multiple times, my strongest tip is to build in a two-hour minimum connection in whichever European gateway your airline uses before the final hop to Dubrovnik, since regional aircraft servicing DBV often depart from separate terminals or require a bus transfer airside—tight connections here are where itineraries unravel, not on the transatlantic leg. Dubrovnik's own airport is compact and efficient, but it's roughly 20 minutes from the Old Town, so arrange transport in advance during peak summer season when taxi queues can be brutal. Seasonally, this route rewards patience: April, May, September, and October not only offer better award and business class availability but also spare you the cruise-ship crowds that flood the Old Town in July and August.
Given the multi-carrier, multi-connection complexity of this routing, fares fluctuate more than on simpler transatlantic city pairs—setting up automated fare alerts is the smartest way to catch premium-cabin pricing anomalies before they disappear.