Southwest Florida's Gulf Coast crowd heading to Bavaria faces a genuine routing puzzle, since there's no nonstop option and Nuremberg's compact airport doesn't support widebody service from the US. Business class from Fort Myers to Nuremberg realistically means connecting through a major East Coast or European gateway, with Delta, American, and United all offering viable one-stop or two-stop itineraries via their transatlantic hubs. Delta's strongest play routes through Atlanta or JFK into Amsterdam or Paris on a Delta One suite with sliding privacy doors, then a regional partner hop into Nuremberg; American typically funnels through Charlotte or Philadelphia into London Heathrow or Frankfurt in their Flagship Suite before a short intra-European connection; United leans on its Polaris seat out of Newark or Chicago into Frankfurt or Munich, both of which offer far more frequent onward service to Nuremberg than most travelers expect.
Having routed through Frankfurt and Munich repeatedly on this exact itinerary, I'd steer travelers toward Munich as the connecting point whenever schedules allow — it's roughly an hour's drive or a quick rail hop from Nuremberg, and misconnections there are easier to recover from than in Frankfurt's sprawling terminals. My insider tip: book the Munich connection with at least a two-hour buffer during winter months, since de-icing delays are common between December and February and can cascade into missed regional legs that aren't heavily protected by codeshare rebooking desks.
Seasonally, January through March and October into November consistently produce the most attractive business class fares on this corridor, as Bavarian trade fair season and Oktoberfest crowds taper off and transatlantic demand softens before the summer surge. Given the multi-carrier, multi-connection complexity of this route, setting up automated fare alerts is genuinely the smartest way to catch the rare premium-cabin discounts before they vanish.