Salzburg's Mozart-scaled airport wasn't built for transatlantic jets, which is precisely why every seasoned traveler booking business class from Fort Myers to Salzburg accepts upfront that the routing runs through a major European or East Coast hub rather than nonstop. There is no direct service on this pairing—Delta, United, and Austrian Airlines all require a connection, typically through Atlanta, Newark, or a European gateway like Frankfurt, Munich, or Vienna. The most seamless option I've found repeatedly is connecting through Munich or Vienna on Austrian Airlines metal (or a Star Alliance codeshare via United), landing you close enough to Salzburg for a scenic 90-minute transfer through the Austrian Alps foothills rather than another cramped puddle-jumper.
Delta's Delta One suite, with its sliding privacy door, is worth routing for if you can position through JFK or Atlanta before joining a joint-venture partner across the Atlantic; United's Polaris business class, especially on the 767 or 777 fleet out of Newark, remains a dependable if less flashy alternative with lie-flat comfort and decent lounge access at EWR's Polaris Lounge. Austrian Airlines itself, once you're within Europe, flies a more modest but perfectly comfortable long-haul business product on its 777 and 767 aircraft, and connecting onward to Salzburg via Vienna lets you experience Austrian's home-turf service before a short hop on a Dash 8 or Embraer regional jet. My insider tip: build in a two-to-three hour buffer in Vienna or Munich regardless of official minimum connection times, since Salzburg-bound regional flights often depart from bus-gate terminals that require extra walking and re-screening, especially during winter ski season congestion.
January through March and again in October and November are consistently the softest months for premium fares on this corridor, largely because Salzburg's peak leisure crush arrives around Christmas markets and summer festival season, leaving shoulder months comparatively quiet for award space and fare sales. Given the fluctuating routings and lack of a one-stop nonstop solution, this is a route where setting up automated fare alerts pays real dividends, letting you pounce the moment Delta, United, or Austrian release a rare well-priced business class fare between these two very different but equally rewarding destinations.