Southwest Florida's proximity to Adriatic Croatia has always struck me as a mismatch that only business class travel can properly resolve, since no nonstop exists and RSW's modest terminal means every journey to Split starts with a connection through a major East Coast or European gateway. There is no direct service on Delta, American, or United from Fort Myers to Split business class; instead, the smartest routings I've flown funnel through Atlanta or JFK on Delta, hooking into a transatlantic leg to Amsterdam or Paris via partner metal, or through Chicago or Newark on United into Frankfurt or Munich before a final hop to Split. American's typical path runs through Philadelphia or Charlotte into London Heathrow, connecting onward. Total elapsed time hovers near 11 hours in the air, though with connections the door-to-door journey often stretches past 15.
Delta's Delta One suite, with its sliding privacy door, is the strongest hard product you'll find on the transatlantic segment, and I've had consistently good luck booking it through Amsterdam, where the connection to Split on a regional partner is short and manageable even after an overnight flight. United's Polaris seats, particularly on the 767 and 777 fleets out of Newark, offer solid lie-flat comfort and decent lounge access at EWR's Polaris lounge before departure. American's Flagship Suite, when available on the transatlantic legs into Heathrow, is worth chasing, though onward connections through LHR's Terminal 3 to Split require padding extra time given the airport's notorious congestion.
My insider tip: fly into Split rather than out on the tail end of summer, since Croatian air traffic control delays cluster heavily in July and August, and the shoulder-season months of April, May, September, and October not only reduce turbulence at Split's compact airport but also align with the softest fares of the year. Given how thin premium inventory is on these connecting itineraries, I'd treat fare tracking as essential rather than optional — setting alerts for this specific city pair will catch the fleeting business class award and revenue releases before they vanish.