Few routes in global aviation demand the patience that connecting between Honolulu and Madeira's Funchal airport requires, and that's precisely what makes getting the routing right so consequential. There is no nonstop option, so business class from Honolulu to Funchal invariably means transiting either the US mainland or a European hub, with London, Frankfurt, or Lisbon serving as the logical gateways depending on whether you fly British Airways, Lufthansa, or TAP Air Portugal for the final leg. My preferred build is HNL to a West Coast gateway, onward to Frankfurt or London on a widebody, then a same-day connection to Funchal — a routing that keeps total journey time reasonable given the roughly 12-hour flying time once you strip out the Pacific crossing. TAP Air Portugal is the only carrier of the three with meaningful frequency into Funchal itself, and their Lisbon hub is worth prioritizing if your itinerary allows, since it minimizes the number of total connections into this small Atlantic island airport.
For the long-haul segments, Lufthansa's rollout of the Allegris business class suite on select 787 and A350 routes is worth chasing if your Frankfurt connection lines up with the right aircraft, though older configurations still fly much of the network, so check equipment before booking. British Airways' Club Suite, with its sliding door and direct aisle access, has become standard on most of their long-haul widebodies out of London and is a reliable choice for the transatlantic stretch. TAP's business product on the Lisbon-Funchal hop is regional and short, so treat that segment as a formality rather than the highlight of your trip — the real comfort investment goes into the transatlantic leg.
One insider tip: Funchal's airport, built on a clifftop extension, can suffer wind-related delays more than travelers expect, so building in a buffer connection window in Lisbon or London rather than a tight same-day transfer will save considerable stress. January, February, March, and again October and November tend to offer the softest business class fares on this corridor, as European leisure demand dips. Given the complexity of routing options across three alliances, setting up fare alerts for this specific city pair is the smartest way to catch a strong business class fare before it disappears.