Seville remains one of Andalusia's most stubbornly non-hub-friendly cities, which means anyone booking business class from Houston to Seville needs to think in terms of European gateways rather than a single carrier's marketing map. There is no nonstop option: the practical routing runs through Madrid via Iberia, through London via British Airways, or through Frankfurt or Munich via Lufthansa, with the Iberia-through-Madrid connection being the most seamless since Iberia operates the IAH-MAD nonstop directly and then hops you down to SVQ on a short regional connection, often on the same ticket and terminal. Total journey time including the connection typically runs 13-14 hours door to door, with the transatlantic leg itself clocking in around 10 hours. Iberia's A330 business class cabin, with its lie-flat seats and direct-aisle access on most configurations, is a comfortable long-haul product, while British Airways routes IAH-LHR on its 787 or 777 fleet, giving access to Club Suite with its sliding door and forward-facing bed — worth the extra connection if you can snag Club Suite availability, since it outclasses Iberia's older business hard product on paper.
I've found Madrid's T4 to be the friendliest connection point of the three for a tired transatlantic arrival — immigration and security are efficient, and Iberia's own lounge network there is a genuine perk if you have a few hours before the SVQ hop. My insider tip: build in a 3-4 hour layover in Madrid rather than a tight 90-minute connection, because Iberia's regional flights to Seville are notoriously prone to gate changes and short-notice schedule shifts, and rebooking on the spot at T4 is far easier than doing so from Seville's small airport if something goes wrong upstream.
Shoulder season — April, May, September, and October — consistently offers the best combination of fare value and weather, since Seville's summer heat is genuinely brutal and airlines price accordingly in July and August. Given how fare availability on all three carriers fluctuates week to week on this itinerary, setting up automated fare alerts is the smartest way to catch a premium-cabin seat before it disappears.