There's no nonstop path linking these two cities, which surprises first-time researchers of this corridor: business class from Houston to Stuttgart always routes through a connecting hub, most commonly Frankfurt, Munich, or occasionally a US gateway like Newark or Washington Dulles depending on carrier. United flies IAH nonstop to Frankfurt on its 787 or 777 with Polaris business class, then hands off to a short Lufthansa hop into Stuttgart. Lufthansa itself often routes passengers via Frankfurt or Munich, with the newer Allegris cabin gradually appearing on select long-haul aircraft, though most Frankfurt runs still fly the well-regarded 747-8 or A340 business product. Delta, meanwhile, typically connects through Atlanta or JFK before joining a transatlantic partner into Germany, making it the least direct option for this particular city pair.
Having flown this corridor repeatedly, I'd steer travelers toward the United-Lufthansa combination if schedule flexibility allows a Frankfurt connection with at least 90 minutes of buffer — Frankfurt's Terminal 1 can be a maze during peak morning bank of arrivals, and Lufthansa's regional jets to Stuttgart depart from a different pier than most long-haul arrivals. My insider tip: book the earliest Frankfurt-Stuttgart connection you can find, even if it means a tight layover, because Lufthansa's afternoon regional flights into STR are frequently affected by cascading delays from Frankfurt's congested airspace. Munich connections, while less common on this specific routing, tend to be smoother operationally and worth requesting if your itinerary allows carrier flexibility.
Seasonality matters enormously here. January through March and again in October and November consistently offer the softest business class fares, as this period avoids both the summer trade fair season in Stuttgart — home to major automotive industry events — and the Christmas market crowds that spike December demand. Because pricing on this route fluctuates with corporate travel patterns tied to Stuttgart's manufacturing base, setting up automated fare alerts is the smartest way to catch a favorable window before it closes.