Nuremberg's compact airport and Franconia's trade-fair calendar make it a surprisingly frequent business destination, yet no airline flies nonstop there from the Midwest, so booking business class from Indianapolis to Nuremberg means embracing a well-chosen connection rather than treating it as a compromise. The practical routing works through Delta via Amsterdam or Atlanta transfers to KLM/Air France metal, American via London Heathrow or a European gateway on British Airways or Finnair, and United via Chicago or Newark connecting onto Lufthansa's network into Frankfurt or Munich before the short regional hop to Nuremberg. In practice, Delta's Amsterdam connection is the most forgiving for these itineraries, offering Delta One suites on the transatlantic long-haul with the reliable Schiphol transfer process, while United passengers should aim to route through Frankfurt on Lufthansa rather than Munich when possible, since Frankfurt's Star Alliance transfer halls handle tight connections into Nuremberg's regional Lufthansa CityLine flights more smoothly.
Having flown this corridor repeatedly for Nuremberg's toy fair and industrial trade shows, I've learned that the real decision point isn't the transatlantic cabin—Delta One, American's Flagship Suite equivalents on partner metal, or United Polaris are all strong—but the connection city. Amsterdam and Frankfurt both offer solid lounge access for premium transfer passengers, and I'd steer seasoned travelers toward Frankfurt if their itinerary allows an extra 45 minutes of buffer, since Nuremberg-bound feeder flights depart from a concourse that's an easier walk than Munich's satellite terminal shuttle. An insider tip few frequent flyers exploit: booking the Indianapolis-to-hub segment as a separate positioning flight on miles, then pairing it with a discounted transatlantic business fare, often unlocks better award availability than searching the full itinerary as one ticket.
January through March and again in October and November consistently produce the softest fares on this Germany corridor, as business travel dips outside Nuremberg's major fair weeks and airlines discount premium cabins to fill them. Given how fragmented these three-airline routings are, and how quickly award space and fare sales disappear on connecting itineraries, setting up automated fare tracking for Indianapolis-Nuremberg business class is the smartest way to catch a favorable pricing window before it closes.