Indianapolis business travelers heading to Vienna face an immediate truth: there's no nonstop option from IND, so the routing you choose matters as much as the cabin you fly. Booking business class from Indianapolis to Vienna typically means connecting through a major East Coast or Midwest hub before crossing the Atlantic — Delta via Detroit or JFK into Amsterdam or Paris with onward partner connections, United via Chicago or Newark with a change in Frankfurt or Munich, or American via Chicago or Philadelphia connecting onto British Airways or Finnair metal. I've flown all three routings enough times to know that United's Newark-Munich-Vienna combination tends to offer the tightest, most reliable connection window, while Delta's Amsterdam routing gives you the bonus of KLM's World Business Class widebody product on the transatlantic leg, a seat I actually prefer for the extra shoulder room.
The transatlantic segment is where the real seat selection matters — Delta's A330 and A350 One Suite cabins with sliding privacy doors are consistently the strongest hard product among the three carriers on this corridor, while United's Polaris seats on 767s and 777s vary meaningfully by aircraft generation, so it's worth checking your specific tail number before booking. American's reliance on oneworld partners means you'll often end up in a Finnair or British Airways business seat for the long-haul leg, which can be a pleasant surprise given Finnair's A350 product. My insider tip: build in a two-hour minimum connection in Munich or Frankfurt during winter months, since de-icing delays are common January through March and can eat into tight layovers that look fine on paper.
The sweet spot for value on this route falls in January, February, March, October, and November, when European demand softens and award space opens up on partner carriers. Given how much routing and aircraft type can shift week to week, I'd recommend setting up fare alerts specifically for this Indianapolis–Vienna corridor rather than checking manually, since the best business class fares here tend to surface briefly before disappearing.