Nantes rarely appears on the radar of American business travelers, which is precisely why the routing from Louisville rewards a bit of planning. There's no nonstop, of course, so the realistic path for business class from Louisville to Nantes runs through Detroit or JFK on Delta, connecting onto Air France's network via Paris-CDG, or alternatively via Frankfurt or Munich on Lufthansa. Delta's transatlantic metal typically features the Delta One suite with sliding privacy doors on widebody aircraft serving Paris, while Air France's connecting flight from CDG down to Nantes is usually a short intra-European hop in a standard regional cabin — the real business class experience happens on the transatlantic leg, not the connector. Lufthansa routes through Frankfurt or Munich offer their own long-haul business product, though Allegris suites are still rolling out fleet-wide, so it's worth checking aircraft type before booking if that specific seat matters to you.
Having flown this connection combination several times, my strong preference is routing through CDG rather than Frankfurt when heading to Nantes — Air France's domestic network out of Terminal 2E has more frequent Nantes departures throughout the day, which matters if your inbound transatlantic flight runs late. An insider tip few mention: CDG's Terminal 2E connections for domestic French flights sometimes require a bus transfer to remote gates, so build in more buffer time than the posted minimum connection window suggests, especially during winter fog delays that occasionally plague Charles de Gaulle in December and January.
Seasonally, January through March and again in October and November tend to offer the softest fares for this Kentucky-to-Brittany pairing, since neither leisure nor peak business travel patterns compete heavily for these off-season windows. Given how these fares fluctuate with fuel surcharges and connection routing changes, setting up automated fare alerts is the smartest way to catch a favorable business class fare before it disappears.