There's something almost perverse about the logistics of getting from a Kentucky bourbon warehouse to the marble alleyways of Zadar, and yet the routing puzzle is precisely what makes this itinerary worth doing properly. No airline offers a one-stop nonstop, so business class from Louisville to Zadar always involves a connection—typically through Frankfurt or Munich on Lufthansa, or via Istanbul on Turkish Airlines, both of which then feed into Croatia Airlines' regional network for the final hop down the Adriatic coast. The realistic total journey time runs well beyond the ~10 hour flying time once you account for the transatlantic leg and the short connector, so I always tell people this is a two-flight, one-day affair rather than a single marathon segment.
My preference on this routing is Lufthansa's transatlantic segment, ideally booked on a 747-8 or A350 with the newer Allegris business seats now rolling out on select US routes—ask specifically when booking, since older business class cabins still fly some Louisville-adjacent connections. Frankfurt is the smarter hub of the two for this itinerary: its dedicated non-Schengen business lounges are calmer than Munich's during peak summer beach season, and the walk to intra-European gates is shorter, which matters when you're catching a tight Croatia Airlines connection. Turkish Airlines via Istanbul is the wildcard worth considering off-season, since their business class lounge is a destination unto itself and the carrier often prices aggressively into secondary European markets like Zadar that lack strong nonstop demand.
The insider move here is timing: Zadar's tourist crush peaks July through August, which distorts both award availability and connecting fares, so April, May, September, and October deliver not only better weather for exploring Dalmatia without crowds but noticeably more open business class inventory on the Frankfurt and Munich connections. Given how thin and seasonal capacity is on this corridor, setting up fare alerts rather than checking manually is the only sane way to catch a well-priced business class fare before it disappears.