Memphis doesn't hand you a nonstop path to Madeira, so anyone chasing business class from Memphis to Funchal needs to think like a route planner rather than a passenger buying a single ticket. There is no nonstop option here — the reality is that Memphis to Funchal business class travel requires a connection through a major European or transatlantic hub, and the routing you choose shapes the entire experience. TAP Air Portugal is the natural carrier of choice given its Lisbon hub sits closest to Funchal, and TAP's business class on its A321neo and widebody fleet offers a comfortable, if not flashy, lie-flat product on longer sectors — ideal for the final short hop into Madeira's dramatic clifftop runway. British Airways routes through London Heathrow, where Club Suite on the 777 and A350 fleet delivers a genuine door-equipped suite, a meaningful upgrade if you're building an itinerary around a London stopover. Lufthansa, connecting via Frankfurt or Munich, is worth watching for aircraft rotating Allegris cabins on select long-haul routes, though older Business Class configurations still appear on many frames, so checking your specific aircraft before booking pays off.
My own routing preference has been Memphis–Frankfurt–Lisbon–Funchal on Lufthansa and TAP in combination, since Frankfurt's connection times tend to be more forgiving than Heathrow's during peak summer congestion, and Lisbon's compact terminal makes the final Funchal leg painless even on a tight layover. One insider tip: book the Funchal approach for a daylight arrival if possible — the descent over Madeira's coastline is genuinely one of the more spectacular business class arrivals in Europe, and window seats on the left side heading in from Lisbon offer the best view.
Deal-wise, January through March and October into November are consistently softer months for fares on this corridor, as Madeira's shoulder season keeps both leisure and business demand lower. Given the multi-carrier routing complexity and fluctuating award space through Lisbon, Heathrow, and Frankfurt, setting up automated fare alerts is the smartest way to catch a premium seat before it disappears.