Belfast's linen mills and Titanic Quarter deserve better than a cramped middle seat after a transatlantic slog, which is exactly why the routing matters so much on this itinerary. There's no nonstop option here—business class from Nashville to Belfast always routes through a major hub, and the three carriers worth considering are Delta, American, and United, each funneling passengers through Atlanta/JFK, Charlotte/Philadelphia, or Chicago/Newark respectively before the long ocean crossing into Belfast City or, more likely, Dublin as a practical alternative given BFS's limited widebody infrastructure. In my experience, Delta's connection through JFK onto a transatlantic partner (or its own metal to Edinburgh/Dublin with a short hop over) tends to offer the smoothest experience, particularly if you can land a Delta One suite with the sliding door on the long-haul segment—a meaningful upgrade over the older reverse-herringbone seats still flying some Atlanta routes.
American's transatlantic business product, Flagship Suite on select 777-300ERs and 787-9s, is worth chasing if your routing runs through Philadelphia or JFK into London or Dublin, since the seat's privacy and storage beat United's older Polaris cabins on non-refreshed aircraft. United, meanwhile, has been steadily rolling out its updated Polaris seats on 767 and 777 aircraft through Newark and Chicago, so it's worth checking the specific tail number before booking—an insider move most travelers skip. My personal trick: search availability into Dublin rather than Belfast directly, then book the short regional connector separately, since award space and premium cabin frequency into Dublin dwarfs what's offered into BFS.
Seasonality favors patience here—January through March and again in October and November consistently produce softer demand and better business class availability, since Northern Ireland's tourist surge concentrates around summer and the Christmas markets. Given how much these fares fluctuate week to week across three competing carriers and multiple routing options, setting up automated fare alerts is genuinely the smartest way to catch a premium seat before it disappears.