Toulouse rarely appears on American business travelers' radar, yet Airbus's headquarters city has quietly become one of the more interesting connecting puzzles out of Nashville. There is no nonstop option, so business class from Nashville to Toulouse requires a transatlantic hop paired with a European connection—typically through Atlanta or Paris on Delta and Air France, or via a US gateway to Frankfurt or Munich on Lufthansa. The most efficient routing I've found pairs a Delta One flight from Atlanta, in their Airbus A330-900 or A350 suites with sliding doors, into an Air France connection at Paris-CDG down to Toulouse on a regional jet, where business class is a domestic-style front cabin—modest, but the short hop is easy after a long-haul lie-flat sleep. Lufthansa's option through Frankfurt or Munich brings their newer Allegris business suites on select long-haul aircraft, though not guaranteed on every Nashville-originating itinerary, so it's worth checking the specific aircraft before booking.
Having routed through CDG more times than I can count, my insider tip is this: if your connection lands you at Terminal 2E and departs from Terminal 2F for the Toulouse leg, budget extra time, because the walk and security recheck between those halls is longer than most itineraries suggest, and Air France's TLS departures often depart from remote gates requiring a bus. Arriving into CDG on a Delta or Air France joint-venture ticket also gives you lounge access in Terminal 2E, which is a comfortable place to decompress before the final leg into southwestern France. Seasonally, Toulouse traffic ebbs in winter and shoulder months, which works in travelers' favor.
January, February, March, October, and November consistently produce the softest business class fares on this corridor, as Airbus-related corporate travel and summer leisure demand both taper off. Because pricing on this three-carrier, single-connection route fluctuates with joint-venture fare rules between Delta, Air France, and Lufthansa, setting up automated fare alerts is the smartest way to catch a premium seat when it briefly dips.