Birmingham's second city charm rarely gets the nonstop treatment from the New York area, which is precisely why savvy travelers routing business class from Newark to Birmingham need to understand there's no direct option—United, British Airways, and American all require a connection, most sensibly through London Heathrow. That single fact matters enormously for planning: British Airways operates one-stop itineraries pairing a Newark–Heathrow segment in their Club Suite—the airline's fully enclosed, direct-aisle-access seat rolled out across their long-haul fleet—with a short domestic hop to Birmingham, often on a narrowbody with a scaled-down but perfectly serviceable business cabin. United passengers typically transit via Heathrow or occasionally through their own hubs with a codeshare partner, flying Polaris seats on the transatlantic leg before dropping into a partner carrier for the final stretch.
Having flown this connection more times than I can count, my strongest advice is to build in at least a 2.5-hour buffer at Heathrow if you're transferring terminals, since British Airways' long-haul arrivals often land at Terminal 5 while some connecting flights depart from a different pier—tight connections here cause more missed flights than almost any other UK gateway I've tracked. The insider move few travelers know: booking the BA Heathrow-Birmingham leg as part of a single through-ticket, rather than separately, protects you if the transatlantic segment runs late, since BA will rebook you free of charge on the next available flight—something that doesn't apply if you've stitched together separate reservations.
Seasonally, January through March and again in October and November consistently offer the softest business class demand on this corridor, as leisure travel to the Midlands dips and corporate travel hasn't yet picked back up post-holidays. Given how thin business class inventory can be on the connecting Birmingham leg specifically, I'd strongly recommend setting up fare alerts rather than checking manually—availability shifts quickly, and catching a release the moment it happens makes all the difference on this route.