Santorini's caldera views are worth every mile of the journey, but getting there in comfort requires strategic routing since there's no nonstop option from New Jersey to that volcanic outcrop in the Aegean. The honest answer for anyone researching business class from Newark to Santorini is that you'll connect through a major European hub, with total journey time (including the layover) typically running 13-15 hours against roughly 11 hours of actual flight time. Lufthansa via Frankfurt or Munich offers the most seamless experience, particularly if you can snag their new Allegris business class on the transatlantic leg—a genuine leap forward with sliding privacy doors and adjustable lighting that Lufthansa has been rolling out fleet-wide. British Airways routes through Heathrow, where their Club Suite (with direct aisle access and a proper door) has become the gold standard for competitors to chase, and Terminal 5's dedicated Concorde Room lounges make the connection genuinely pleasant rather than a chore. Aegean Airlines, Greece's flag carrier, typically handles the final short hop from Athens to Santorini, and while their business product is regional rather than long-haul lie-flat, it's a mercifully quick 45-minute puddle jump.
My insider tip after years flying this corridor: book the Aegean connecting flight with enough buffer time—at least two hours in Athens—because Santorini's small airport experiences notorious weather delays and gusty crosswinds that can cascade into hour-long ground stops during peak summer months. This is precisely why shoulder season matters so much here. April, May, September, and October not only bring softer fares on the transatlantic long-haul segments, but they also spare you the July-August crowds that turn Fira's caldera pathways into a slow shuffle.
Given how fare structures shift week to week on this three-airline, one-stop routing, setting up automated price tracking for the Newark-Santorini corridor will save you from overpaying and help you pounce the moment premium cabin availability opens up on your preferred dates.