There's no nonstop path between Newark and Valencia, which actually works in your favor: routing through Madrid, London, or Frankfurt lets you sample three distinct European business class products before touching down on Spain's Mediterranean coast. Booking business class from Newark to Valencia typically means connecting onto a short intra-European hop, and the factual reality worth noting upfront is that no carrier currently flies this exact city pair nonstop — Iberia, British Airways, and Lufthansa all funnel passengers through their respective hubs. Iberia's Madrid connection is the most seamless choice for this itinerary, since their long-haul A330neo and A350 business class seats (all-aisle-access, direct-aisle-access suites) transition naturally into a short domestic hop on the same ticket, often through the same terminal.
Having flown all three routings repeatedly, I'd steer discerning travelers toward the Iberia option via Madrid whenever schedules align, largely because Iberia's Terminal 4S at Madrid-Barajas is purpose-built for smooth international-to-domestic connections, with dedicated fast-track lanes for business class and Oneworld elite passengers. British Airways via London offers Club Suite on the transatlantic leg — a genuine step up in privacy with its sliding door — but Heathrow's Terminal 5 connections to Valencia can eat into your buffer time, so I never book less than two hours there. Lufthansa via Frankfurt is worth considering if you're chasing Allegris seats on newer aircraft, though availability on this specific configuration remains inconsistent for now, so confirm your equipment before counting on it.
Shoulder season — April, May, September, and October — consistently delivers the best combination of fare value and pleasant Valencia weather, avoiding both the summer crush and winter's thinner schedules. My insider tip: search Iberia's Madrid connection with a deliberately long layover (3-4 hours) during the paella-and-tapas hours, since Iberia occasionally allows a same-day stopover fare with no extra cost, letting you sneak in a Madrid meal before Valencia. Given how fares on this three-airline route fluctuate with connection routing and season, setting up automated fare alerts is the smartest way to catch a premium seat before it disappears.