John Wayne Airport's runway restrictions mean there's no nonstop path to the Athens, so every itinerary in business class from Orange County to Athens routes through a domestic or East Coast gateway before crossing the Atlantic — and understanding which connection to choose matters as much as the airline you pick. American routes travelers through its Philadelphia or Charlotte hubs onto AA-metal or partner aircraft, though for this itinerary I've found the more consistent premium product comes via Delta's JFK or Atlanta connections, where you'll often find the A330-900 or A350 fitted with Delta One suites featuring a sliding door — a meaningful upgrade over older reverse-herringbone cabins on legacy 767s still flying some transatlantic Delta routes. United, meanwhile, typically funnels SNA passengers through Newark or Chicago, occasionally putting you on the 767-400 with Polaris seats, a dependable if less flashy product than Delta's newest suites.
Having flown this corridor numerous times, my strongest recommendation is to build in at least a two-hour buffer at your connecting hub during summer months, when transatlantic congestion at JFK and Newark creates delays that ripple backward into domestic legs — arrive at SNA with plenty of runway yourself, since the airport's compact single terminal moves quickly but security lines swell during peak SoCal commuter hours in the early morning. An insider trick many travelers miss: booking the SNA-to-hub segment as a separate reward ticket on the same alliance often opens up better business class award space than searching the full itinerary as one booking, since domestic saver fares and international premium inventory are priced independently in most search engines.
Shoulder season — April, May, September, and October — consistently delivers the best combination of fare value and pleasant Athens weather, avoiding both the brutal July heat and winter's thinner Aegean daylight. Given how much these fares fluctuate week to week depending on carrier and connection, setting up automated alerts to track pricing on this specific Orange County–Athens business class corridor will save you both money and the tedium of manual searching.