There's no nonstop escape from John Wayne Airport to the Canary Islands, which is precisely why routing strategy matters more on this itinerary than almost any other transatlantic booking I make. Business class from Orange County to Tenerife requires a connection—there is no way around it—and the honest answer is that the routing you choose shapes the entire experience: Lufthansa via Frankfurt, British Airways via London Heathrow, or Iberia via Madrid, each delivering roughly 11 hours of total flight time but wildly different cabin experiences and layover characters.
Of the three, I steer regular flyers toward Iberia's Madrid connection whenever schedules align, since Madrid-Barajas offers a manageable transfer and Iberia's A330 business class—lie-flat with direct aisle access on most configurations—feels underrated next to its British and German rivals. British Airways routing through Heathrow puts you in their Club Suite on the transatlantic leg out of SNA's connecting gateway (typically via LAX or a domestic hop to a BA gateway), which is worth chasing for the privacy doors alone, though Heathrow's T5 connections can eat an hour you didn't budget for. Lufthansa's Frankfurt routing increasingly features their new Allegris business seats on select aircraft, though it's still being phased in fleet-wide, so I always check the specific equipment before booking rather than assuming. My insider tip: fly into TFS in the early afternoon Canary Islands local time whenever possible—flights timed this way avoid the late-evening arrival crunch when rental car counters and hotel shuttles thin out on this island.
Seasonally, April, May, September, and October reward patient shoppers, as European carriers adjust award and premium cash inventory ahead of and after the peak summer surge to the Canaries. Given how fluid pricing is across three different hub strategies, I'd rather let a fare tracker watch Madrid, Heathrow, and Frankfurt routings simultaneously than refresh search engines myself every morning.