Salzburg's postcard-perfect Altstadt doesn't have a business class runway of its own—there's no nonstop from Pittsburgh, so every premium itinerary funnels through a major hub, and that connection choice is where seasoned flyers separate a good trip from a great one. For business class from Pittsburgh to Salzburg, the most reliable routing pairs Delta or United's transatlantic metal with Austrian Airlines' regional hop from Vienna, since OS operates the only meaningful onward service into SZG and its short intra-European business cabin (a blocked middle seat with enhanced catering) makes for a civilized final leg after a long night over the Atlantic. Delta typically routes through JFK or Boston with its Delta One suites—sliding doors and all on 767 and A330 aircraft—while United often connects via Newark or Washington Dulles, deploying Polaris seats on its 767-300ER or 777-200 depending on the season.
Vienna International Airport is the linchpin here, and it rewards a little planning: give yourself at least 90 minutes for the connection even with priority disembarkation, since Austrian's home hub, while efficient, funnels international arrivals through passport control that can back up during peak summer tourist season. My insider tip, gleaned from doing this routing more times than I can count, is to book the OS domestic-style hop as a separate ticket only if you're an experienced connector comfortable with Schengen transit logistics—otherwise keep it on one itinerary so Austrian's ground staff rebooks you automatically if Delta or United runs late into VIE.
January through March and again in October and November are the sweet spot for this journey, when both Christmas market crowds and summer festival tourists have thinned and premium award space opens up on the transatlantic legs. Given how fare and award availability fluctuates week to week on this three-carrier routing, setting up automated fare alerts is the smartest move you can make before locking in dates.