Valencia remains one of the more rewarding puzzles in transatlantic routing, and after piecing together this itinerary a dozen different ways, I can say with confidence there's no nonstop shortcut: business class from Portland to Valencia always routes through a major hub, typically London Heathrow, Madrid, or occasionally a Northeast gateway before the transatlantic hop. The most reliable combination pairs American Airlines out of PDX with either British Airways or Iberia across the Atlantic, and the total journey time, door to door, generally lands around 15-17 hours including connections, though the core long-haul segment runs approximately 11.5 hours on a comparable point-to-point basis. That's a mouthful for a getaway to Spain's third city, but the payoff is worth the routing gymnastics.
My preferred build is American Airlines from PDX to a hub like Dallas or Philadelphia, then transferring onto British Airways' Club Suite — the airline's fully enclosed, door-equipped business seat now standard on most 777 and 787 aircraft — for the crossing into London. From there, a short BA or Iberia hop down to Valencia closes the loop. Iberia's A330 and A350 business class, while less flashy than Club Suite, offers a comfortable lie-flat product and the advantage of routing through Madrid-Barajas, which often has smoother connections into VLC than Heathrow's congested T5. If you're transiting Heathrow, build in at least 90 minutes — security recheck for connecting passengers can bottleneck badly in peak summer months.
Seasonality matters more on this route than most people realize: April, May, September, and October consistently offer the best combination of value and weather, since Valencia's brutal July-August heat pushes leisure demand (and pricing) into the shoulder seasons instead. An insider trick worth noting — Iberia frequently prices Madrid connections more attractively than BA's London routing for the same Valencia arrival date, so it pays to search both carriers separately rather than relying on a single multi-city search engine. Given how much these fares fluctuate week to week on a route with no consistent nonstop competition, setting up automated fare alerts is genuinely the smartest way to catch a business class window before it closes.