Seville remains one of Andalusia's most rewarding destinations precisely because it's still awkward to reach, and that's exactly why route intelligence matters so much here: there is no nonstop option, and business class from Raleigh to Seville requires a routing through either London Heathrow via British Airways or a Madrid/one-stop connection via American Airlines and Iberia's transatlantic partnership. The most reliable itinerary I've flown repeatedly is RDU-LHR on American's 787 or 777 (their Flagship Business, lie-flat with direct aisle access on the 777), connecting onto British Airways' Club Suite for the LHR-SVQ hop — a genuine upgrade in privacy thanks to Club Suite's sliding door, even on the short intra-European sector. Alternatively, routing through Madrid via Iberia puts you into their A330 or A350 business cabin, with Iberia's newer A350 seats offering direct aisle access as well, before a short onward connection to Seville on a regional aircraft.
Having connected through both hubs multiple times, my strong preference is Madrid over Heathrow when schedules allow: immigration and security at Barajas are markedly faster than Heathrow's Terminal 5 queues, and Iberia's Business lounge in T4S is a genuinely relaxed place to reset before the final short hop south. One insider tip worth noting — Iberia's SVQ arrivals are modest, so if you're connecting onward with checked bags, build in extra buffer during Seville's Feria de Abril in April, when local ground handling slows considerably despite otherwise being peak shoulder season for fares.
April, May, September, and October consistently offer the strongest combination of pleasant Andalusian weather and softer transatlantic business class pricing, as summer heat and holiday demand push fares upward from June through August. Given how much these fares fluctuate week to week across three carriers and two very different routings, setting up automated fare alerts is the smartest way to catch a premium seat to Seville before the window closes.