There is no nonstop path between the high desert of Nevada and the shipyards of Belfast, and after two decades of connecting through nearly every plausible hub, I can tell you that the routing you choose matters more than the airline logo on the tail. Business class from Reno to Belfast always requires at least one connection, typically funneling through Salt Lake City, Los Angeles, or San Francisco before crossing the Atlantic via a major eastern gateway like New York-JFK, Chicago, or Washington Dulles — the three carriers serving this corridor, Delta, American, and United, all route their premium transatlantic metal through these hub-and-spoke networks rather than offering anything direct. Total journey time typically runs 14 to 17 hours including connections, well above the roughly 10-hour transatlantic flight time itself.
My preference on this route is Delta, whose Delta One suites on the A330-900neo or A350 (when scheduled on the transatlantic leg out of JFK or Boston) offer sliding privacy doors and genuinely restful lie-flat seats — a meaningful upgrade if your connection routes you through JFK's Terminal 4, which has matured into a solid Delta hub with a proper Sky Club. United counters with Polaris seats out of Newark or Chicago O'Hare, featuring the same door-equipped suite on widebody aircraft, while American's Flagship Suite, when available on JFK or Philadelphia departures, rounds out a competitive field. My insider tip: build in a 2.5-3 hour connection window at your US gateway rather than the minimum legal connection, since domestic-to-international transfers from Reno regularly hit weather delays over the Sierra in winter months, and missing a tight connection here means rebooking onto a red-eye the following day.
January, February, March, October, and November consistently offer the softest fares for this itinerary, as Belfast sees a lull between its lively summer tourist season and December's Christmas market crowds. Because pricing on connecting itineraries like this one fluctuates constantly based on which hub and aircraft get assigned, I'd strongly recommend setting up automated fare alerts to catch the inevitable dips before they disappear.