There's no nonstop way to bridge Utah's mountains and the Cycladic caldera, which is precisely what makes routing strategy the whole game when booking business class from Salt Lake City to Santorini. The honest answer, for anyone asking, is that this journey always requires at least one connection—typically through Frankfurt, Munich, London, or Athens—since no carrier flies SLC-JTR directly, and total travel time runs around 12.5 hours of flying plus connection time. My preferred routing is Lufthansa via Frankfurt or Munich, where the newer Allegris business class (still rolling out fleet-wide, so worth checking your specific aircraft) offers sliding doors and genuine privacy on the transatlantic leg, before transferring to a short intra-European hop into Athens and onward to Santorini on Aegean Airlines. British Airways via London Heathrow is the other reliable option, and their Club Suite—with its own door and direct aisle access—makes the long Salt Lake City to London segment feel far shorter than it is; just budget extra time at Heathrow's Terminal 5 if you're connecting onward to Athens before the final Aegean hop.
The insider move here is booking the SLC–Europe long-haul in business class and the short Athens–Santorini connector separately through Aegean, since award and revenue pricing on that puddle-jump segment rarely aligns with the transatlantic fare buckets—pairing them yourself often unlocks better seat availability than a single through-ticket search. Aegean's A320 business cabin is modest, essentially a blocked middle seat, but it's brief and the airline's punctuality into JTR is excellent even during the volatile summer meltemi wind season, which is exactly why I steer clients toward April, May, September, and October departures, when Mediterranean winds are calmer and fares soften after the June-August surge.
Given how few award seats Lufthansa and BA release on this corridor, and how quickly Aegean's connector inventory shifts, setting up fare alerts well before your travel window is the smartest way to catch a premium seat before it disappears.