After a dozen redemptions on this itinerary, I can tell you there's no nonstop shortcut: business class from San Antonio to Bucharest always routes through a major hub, and the routing you choose shapes the entire journey. Delta passengers typically connect via Atlanta or JFK before transferring to a partner for the transatlantic leg, while Turkish Airlines and TAROM (RO) route through Istanbul, giving you access to Turkish's excellent lie-flat business product and their much-loved catering, including the à la carte "Turkish Delight" service that still sets the tone for the entire trip. The most reliable factual anchor for planning: total flight time from San Antonio to Bucharest runs approximately 12 hours of air time, though with connections the full door-to-door journey typically stretches to 15-18 hours depending on layover length.
My preferred build is SAT–Istanbul on a domestic-to-international connection, then IST–OTP on Turkish's short intra-European business cabin, which, while not lie-flat, comes with a surprisingly generous meal service given the short hop. If Delta's routing works better for your schedule, look for Delta One suites on the transatlantic segment out of JFK or Atlanta — the sliding door and direct-aisle access make the long haul genuinely restful, a meaningful upgrade if you're connecting onward to Southeastern Europe where onward service (TAROM to Bucharest, or Turkish's continuation) is comparatively modest.
One insider tip: build in at least a 2.5-hour connection in Istanbul if flying Turkish, since IST's business lounge, while excellent, sits a long walk from the international gates serving OTP-bound flights, and rushing that transfer erodes the whole point of flying business. January through March and October through November remain the sweet spot for this routing, as Romanian tourism demand is low and transatlantic carriers discount award and revenue fares accordingly. Given how much these fares fluctuate hub to hub, setting up automated fare tracking for this specific city pair is the smartest way to catch a premium seat before it disappears.