Seville's compact airport has no direct link to Texas, so every seasoned traveler booking business class from San Antonio to Seville needs to think in terms of gateway cities rather than nonstop fantasies. The practical answer: there is no nonstop service between SAT and SVQ, and the most reliable routing pairs American Airlines out of San Antonio with a transatlantic partner—either American's own metal via DFW to Madrid or London, or a switch to British Airways or Iberia for the final leg into Andalusia. Having flown this corridor a dozen times, I favor the DFW–LHR–SVQ path on British Airways, using their Club Suite on the long-haul segment—a fully enclosed suite with direct aisle access that makes the transatlantic crossing genuinely restorative before a short Iberia hop finishes the job.
The alternative worth serious consideration is routing through Madrid on Iberia, whose A330 and A350 business class cabins offer lie-flat seats and a distinctly Spanish culinary program—jamón, good sherry, real coffee—that eases you into the country's rhythm before you've even landed. Madrid-Barajas also has excellent connectivity to Seville via short Iberia regional hops, and clearing immigration in Madrid rather than a smaller Spanish airport tends to move faster given the volume of dedicated EU/non-EU lanes. My insider tip: when connecting through London, request a same-day British Airways/Iberia through-check at DFW; agents there can often protect your bags all the way to SVQ even across separate tickets if you ask specifically for an interline agreement, saving you a baggage claim scramble in Heathrow's often-congested Terminal 5 connections area.
Shoulder season—April, May, September, and October—consistently offers the strongest premium-cabin availability and the most temperate Andalusian weather for your arrival, avoiding both summer's brutal heat and winter's thin schedules. Because fares on this Texas-to-Spain corridor swing significantly with fuel surcharges and seasonal demand from Iberia and BA, setting up automated fare alerts is the smartest way to catch a business class fare worth committing to before it disappears.