Rhodes has long rewarded patient planners, and after years of routing through half of Europe to reach this Dodecanese gem, I can say confidently that there is no nonstop option for business class from San Jose to Rhodes — every itinerary requires at least one connection, typically through London, Frankfurt, or Munich, with a possible second hop through Athens on Aegean Airlines. That reality shapes the entire booking strategy: the smartest routings pair a long-haul transatlantic business cabin with a shorter European carrier for the final leg into RHO, since Rhodes' airport handles mostly narrowbody and regional traffic.
My preferred build is British Airways out of San Francisco (the more practical gateway than SJC itself) in their Club Suite — the door-equipped, fully flat suite now standard on their 777 and A350 fleet — connecting through Heathrow's Terminal 5, which offers a seamless business-class transfer without re-clearing security in most cases. Lufthansa is the other strong contender, especially now that Allegris cabins are rolling out on select 787 and A350 routes from the West Coast; landing in Frankfurt or Munich gives you access to their excellent business lounges before a short Aegean Airlines or Lufthansa regional hop to Rhodes. Aegean itself doesn't operate long-haul business product, but its short-haul business class on the Athens–Rhodes or Munich–Rhodes segments is comfortable and refreshingly uncrowded, with real Greek hospitality that sets the tone for the island ahead.
One tip few travelers know: flying into Rhodes on a late morning arrival lets you clear the small terminal quickly and reach Old Town before the afternoon cruise-ship crowds hit. April, May, September, and October are the sweet spot — warm Aegean light, thinner tourist crowds, and noticeably better award availability on both BA and Lufthansa. Given the complexity of routing and the seasonal swings in premium fares on this itinerary, setting up fare alerts for San Jose to Rhodes business class is the easiest way to catch the rare moments when pricing and availability align.