Strasbourg's modest airport handles no long-haul traffic, which means every itinerary in business class from San Jose to Strasbourg requires a connection, typically routed through Paris CDG, Amsterdam, or Frankfurt, with a short regional hop completing the journey. There's no nonstop option out of Mineta San Jose International for this city pair, so the routing itself becomes part of the trip's character. Delta and Air France both offer strong one-stop options via Paris: Delta's A350 business class out of SFO or SJC-adjacent hubs (often requiring a domestic connection first) features their newer suites with sliding doors, while Air France's 777 or A350 business cabins connect efficiently into CDG, where the SkyTeam terminal makes the onward TGV-style regional flight or short hop to Strasbourg relatively painless. Lufthansa routes through Frankfurt, and depending on aircraft assignment you may find yourself in the new Allegris business suite — a meaningful upgrade over the airline's older staggered seats, though availability on this specific chain of flights can be inconsistent, so it's worth checking equipment before booking.
Having flown this general corridor repeatedly, my strongest insider tip is this: book the Strasbourg feeder flight as a separate, flexible regional ticket rather than locking it into the same PNR as your long-haul segment, especially through CDG, where connection times under 90 minutes can feel tight given terminal transfers between Air France's hub concourses. Arriving into Frankfurt gives more buffer, as Lufthansa's regional gates connecting toward eastern France are generally closer to the international arrivals area. Seasonally, this route sees the best business class award and paid fares in January, February, and March, when transatlantic demand dips after the holidays, and again in October and November before the winter markets rush begins — Strasbourg's famous Christmas market season drives a real spike in late November and December pricing.
Given the multi-airline, multi-connection nature of this route, fares shift often based on which hub and aircraft get assigned to your itinerary, so setting up fare alerts for San Jose–Strasbourg business class is genuinely the smartest way to catch the periodic drops before they disappear.