There's no nonstop path linking coastal Georgia to the Cycladic cliffs of Santorini, which means the real craft of booking business class from Savannah to Santorini lies in choosing the right connection architecture rather than chasing a single carrier. In practice, this means routing through Atlanta or a major East Coast gateway to reach a European hub — Frankfurt or Munich on Lufthansa, London Heathrow on British Airways, or Athens on Aegean Airlines — before a short hop to JTR. Total journey time runs close to 12 hours in the air alone, but with connections, plan on 15-18 hours door to door. Lufthansa's rollout of Allegris business class is worth chasing on the transatlantic leg if you can find it on the Frankfurt or Munich routing, though not all aircraft on this corridor have it yet, so check the specific equipment before booking. British Airways flyers should aim for the Club Suite on its 777 and A350 fleet out of Heathrow, which offers proper door privacy — a meaningful upgrade over the older Club World cabin still flying on some routes.
I've flown this patchwork routing enough times to know that the final segment into Santorini is almost always a regional narrow-body operated in economy-only configuration by Aegean, so don't expect a lie-flat seat on the last leg — treat your long-haul business class seat as the main event and the JTR hop as a scenic afterthought. My insider tip: book the earliest viable connection into Athens rather than a same-day tight layover, because Santorini-bound flights are heavily weather- and wind-dependent in shoulder season, and Athens gives you built-in flexibility if JTR arrivals get delayed by the notorious Cycladic winds. April, May, September, and October are consistently the sweet spot for both fares and cabin availability, as summer capacity gets soaked up by leisure demand well before school holidays hit.
Because pricing on this three-airline, multi-connection route fluctuates with fuel surcharges and seasonal demand shifts, it's worth setting up fare alerts to track business class movement on this corridor rather than checking manually — the good Allegris and Club Suite availability tends to surface and disappear quickly.