Newcastle's compact airport doesn't see much premium long-haul traffic from the American Pacific Northwest, which is precisely why the routing puzzle matters so much here. There is no nonstop option, so business class from Seattle to Newcastle always involves a connection, and the most sensible answer is routing through London Heathrow on British Airways, whose transatlantic metal on the SEA-LHR sector features the Club Suite — a fully enclosed, direct-aisle-access seat that debuted on the 787-10 and has since spread across much of BA's widebody fleet. Delta and American both fly SEA to London as well (Delta via its joint venture partnership with Virgin Atlantic-style scheduling, American via its own transatlantic metal or codeshare with BA), and either can work if you're chasing SkyMiles or AAdvantage redemptions, but the final London-to-Newcastle hop is typically a short regional connection on a partner carrier rather than a mainline widebody product, so don't expect lie-flat seating on that last leg.
Having flown this connection more times than I can count, my strongest advice is to build in a buffer at Heathrow rather than booking the tightest legal connection — Terminal 5, where BA's transatlantic and domestic UK flights both operate, is efficient, but weather delays on the Seattle-to-London leg during winter months can cascade quickly, and Newcastle-bound feeder flights don't run frequently enough to absorb a missed connection gracefully. The insider move seasoned business travelers use: book the earliest viable transatlantic departure out of SEA, even if it means an early alarm, because it gives you multiple rebooking options into NCL later that same day if things go sideways.
January through March and again in October and November are the sweet spots for this route, as business demand into the UK dips outside summer conferences and the North Sea energy sector's peak travel windows, softening fares on all three carriers. Given how much these fares swing week to week depending on which carrier is discounting its London gateway flights, setting up automated fare alerts is the smartest way to catch a premium seat at a rate worth booking.