Innsbruck's tiny alpine airport, hemmed in by mountains that make for one of Europe's more thrilling final approaches, isn't a place you'll find nonstop service from the American Midwest — and that reality shapes everything about how you should plan this trip. There is no direct routing for business class from St. Louis to Innsbruck; every itinerary funnels through a major hub, and the connection you choose matters as much as the long-haul cabin itself. Delta passengers typically route through Amsterdam or Paris on Air France-KLM metal before a short regional hop to Innsbruck or a transfer to nearby Munich with a scenic train continuation. United's strongest play is via Munich or Frankfurt, feeding onto Austrian Airlines or a connecting partner for the final leg. Austrian Airlines itself, via Vienna, offers the most culturally fitting entry into Tyrol, though STL travelers will need to build a US hub connection first to reach Vienna.
Where this routing gets interesting is the long-haul segment, since that's where you'll spend nine or ten of your travel hours. Delta's A330-900 and A350 business class, with the reverse-herringbone Delta One suite and closing doors, is consistently the strongest hard product you'll encounter on this itinerary, particularly on the STL-adjacent Atlanta or JFK departures. United's Polaris seats, especially on 767 and 777 aircraft, remain competitive but less private. My insider tip: if your itinerary connects through Munich, build in a two-hour buffer and use the Lufthansa Business Lounge there rather than rushing — MUC-INN or the train alternative via Munich Hauptbahnhof runs smoother with daylight on your side, and winter ski-season fog can cause afternoon delays into Innsbruck's short runway.
January through March and again in October and November are your sweet spots, both for redemption availability and softer pricing, since ski season peaks later in December. Given how fluid award space and fares are across three carriers and multiple European gateways, setting up fare alerts for this specific STL-Innsbruck corridor will save you far more legwork than manually refreshing search engines each week.