Salzburg's compact airport, tucked against the Alps and unable to handle widebody long-haul traffic, means there is no such thing as a direct routing from the Midwest — every itinerary in business class from St. Louis to Salzburg funnels through a major European or East Coast gateway before a short connecting hop on Austrian Airlines or its partners. The practical reality for St. Louis flyers is a domestic or transatlantic connection followed by that final regional leg, and the two dominant strategies are Delta via a JFK or Atlanta transfer into a Star Alliance or SkyTeam partner, or United through Chicago or Newark connecting onto Austrian Airlines' own network into Vienna, with a quick rail or short flight finishing the journey to Salzburg. I've routed this trip enough times to know that Vienna is the smarter final gateway rather than forcing a second flight into SZG itself — the Railjet train from Vienna to Salzburg takes under three hours and beats waiting on a tight regional connection after a long haul.
For the transatlantic segment, Austrian Airlines' Business Class on its Boeing 777 fleet, complete with fully lie-flat seating and Do & Co catering, remains the most comfortable option into Vienna, while United's Polaris seats on 767 or 777 aircraft out of Newark offer solid alternatives with reliable lounge access at EWR's Polaris Lounge. Delta's A330 and A350 business cabins, paired with its Delta One suites on select transatlantic routes, are worth watching for STL connections through JFK, particularly given Delta's frequent seasonal upgrades to newer aircraft on European routes. My insider tip: build in a two-hour buffer in Vienna regardless of airline, since immigration lines at VIE can spike unpredictably with tour groups in shoulder season, and that buffer protects your train connection to Salzburg.
Fare patterns on this corridor favor deal-hunters in January, February, March, October, and November, when business class award space and discounted fares open up well before the summer festival rush hits Salzburg. Given how quickly premium inventory shifts on these connecting itineraries, setting up automated fare alerts is the smartest way to catch a favorable business class fare before it disappears.