Tenerife rarely appears on the radar of American business travelers, which is precisely why the routing deserves attention: there is no nonstop option, so business class from Tampa to Tenerife means threading through a major European or transatlantic hub, and the connection you choose shapes the entire experience. Iberia routes naturally through Madrid, where its A330 and A350 business cabins feature fully lie-flat seats with direct aisle access on the widebody fleet—a Barajas layover also lets you sample the airline's revamped lounge before the short hop to the Canary Islands. British Airways passengers will typically connect via London Heathrow, and it's worth knowing that BA's Club Suite—with its sliding door and forward-facing lie-flat seat—is now standard on most of the carrier's long-haul aircraft serving US gateways, making the transatlantic leg genuinely restful even if the Heathrow-to-Tenerife segment reverts to a shorter-haul business product. Lufthansa routes through Frankfurt or Munich, and travelers willing to experience the airline's new Allegris cabin should check aircraft assignments carefully, as rollout remains uneven across the fleet.
Having flown all three combinations, my strongest recommendation is to build in a deliberate layover of six to eight hours in Madrid rather than rushing the connection—Iberia's schedule allows this comfortably, and it turns a fatiguing double-flight day into a chance to shower, eat well, and arrive in the Canaries actually rested rather than depleted. Tenerife's TFS airport is compact and efficient, but rental car lines swell in high season, so those connecting onward to accommodations should prearrange transfers, especially during the shoulder-season surge when European retirees flock south for winter sun.
April, May, September, and October consistently offer the best value and comfort balance, avoiding both winter congestion and summer heat while keeping business class fares more reasonable than peak periods. Given how erratically award and paid business class space fluctuates on this itinerary, setting up fare alerts is the smartest way to catch a favorable opening before it disappears.