Desert-to-island routing rarely gets more interesting than this: there's no nonstop from Tucson, so every itinerary in business class from Tucson to Corfu funnels through at least two connections, typically Tucson–hub–European gateway–Corfu, with total journey time (including layovers) often stretching well beyond the ~12.5-hour flying time itself. Lufthansa via Frankfurt or Munich remains my preferred backbone for this routing, especially now that Allegris cabins are expanding across the fleet—request the newer configuration when booking a transatlantic segment, as the fully-suited Allegris business class dramatically outclasses the older long-haul product still flying on some Munich routes. British Airways, connecting through London Heathrow, offers Club Suite with direct aisle access on most 777 and A350 aircraft serving the transatlantic leg, and Terminal 5's dedicated Club Wing lounges make a multi-hour layover genuinely pleasant rather than punishing.
The final push into Corfu almost always means a switch to Aegean Airlines, whose regional business class—typically an Airbus A320 with blocked middle seats and enhanced service—handles the Athens-to-CFU or European-gateway-to-CFU hop. Athens is the smarter connection point over other Greek gateways if you have any routing flexibility, since Aegean's frequency and reliability into Corfu peaks precisely during the shoulder-season months of April, May, September, and October, when island-bound leisure traffic is lighter and premium cabins on the short intra-European hop are more likely to have award space or last-minute upgrades. My insider tip: book the long-haul segment and the Aegean segment on a single Star Alliance or oneworld ticket rather than separately—this protects you if Athens' notoriously tight connection windows go sideways, and it's a detail many independent bookers miss.
Given how many carrier and cabin combinations exist across this itinerary, fares fluctuate constantly based on which hub and aircraft you land on—reason enough to track this route with automated fare alerts rather than checking manually.