Desert dwellers heading to Baden-Württemberg face a routing puzzle that no nonstop can solve: there is no direct service between Tucson and Stuttgart, so business class from Tucson to Stuttgart always involves at least one connection, typically through a major American gateway before crossing the Atlantic. The most reliable itineraries route through Delta's Atlanta or Detroit hubs, American's hubs in Chicago or Dallas-Fort Worth, or United's Newark or Houston gateways, with the transatlantic leg operated on widebody aircraft featuring true lie-flat seating. I've routed this journey through Chicago on American more than once, connecting onto a partner or joint-venture flight into Frankfurt or Munich with a final short hop to Stuttgart—total elapsed time often exceeds 15 hours door to door once you factor in the connection, even though the transatlantic segment itself clocks in around 10.5 hours of block time.
The real decision point is which US carrier's business product you want to spend the long-haul segment in. Delta's One Suites, now rolling out across their 767 and A350 fleet, offer sliding privacy doors and are worth positioning for if your Atlanta or Detroit connection lines up. American's Flagship Suite, found on select 777-300ERs and 787-9s out of Chicago or Dallas, gives you a similar enclosed suite experience. United's Polaris seats, reliable across their 767 and 777 fleet from Newark or Houston, round out the domestic options—none of these carriers fly the route in-house all the way to Stuttgart, so your last-mile connection is usually on a Star Alliance, SkyTeam, or oneworld partner into Frankfurt, Munich, or Zurich with a regional jet finishing the job into Stuttgart's compact single-terminal airport, where immigration and baggage claim move quickly even during peak periods.
My insider tip: build in at least a 90-minute buffer for the final connection into Stuttgart, since partner carriers sometimes operate from a different terminal than your transatlantic arrival, and Stuttgart's own limited widebody traffic means schedules can be sparse outside midday windows. January through March and October into November consistently produce the softest business class fares on this corridor, as Alps ski traffic hasn't yet peaked and summer demand has faded. Given the multi-carrier complexity of this itinerary, setting up fare alerts across all three US airlines is the smartest way to catch a premium seat at a rate worth booking before it disappears.