After more than a dozen redeye departures out of Palm Beach International, I can tell you that reaching Chisinau in a proper lie-flat seat requires patience and smart routing, since no carrier offers business class from West Palm Beach to Chisinau on a single ticket without at least one connection. The most reliable itineraries route through Delta's transatlantic gateways like JFK or Atlanta, connecting onto Lufthansa or Turkish Airlines metal for the second leg into Moldova's compact but efficient Chisinau International Airport. In practice, Turkish Airlines via Istanbul tends to offer the most consistent business class product on this corridor, with lie-flat seats and their signature onboard chef service on the widebody legs, while Lufthansa's Frankfurt or Munich connections increasingly feature the new Allegris business suites on select aircraft, though not yet fleetwide.
My preferred routing after years of testing this corridor is PBI–JFK on Delta, allowing a comfortable buffer at JFK's Terminal 4 to enjoy the Delta One lounge before a long-haul Delta One suite—complete with direct aisle access and Westin bedding—across to Europe, then a shorter connection onward. If your itinerary instead routes through Istanbul, budget extra time for Istanbul Airport's security recheck, which can eat 45 minutes during peak summer season; arriving business class passengers should head straight for the dedicated Turkish Airlines lounge rather than lingering at the gate area. One insider trick few mention: Chisinau's arrivals hall is small enough that even wide-body arrivals clear customs within 20 minutes, so there's no need to overbuild connection buffers on the inbound side—save that flexibility for your outbound hub instead.
Seasonality matters enormously here. January, February, March, October, and November consistently produce the softest business class fares on this route, as Moldovan diaspora travel spikes around summer and major holidays push award and revenue fares higher. Given the complexity of routing through three different alliances depending on carrier, I'd strongly recommend setting up automated fare alerts for this specific PBI–KIV pairing, since availability across Delta, Lufthansa, and Turkish shifts frequently and the best premium cabin fares rarely last more than a few days once they appear.